Cis-acting genomic elements of the Pas1 locus control Kras mutability in lung tumors
نویسندگان
چکیده
منابع مشابه
Mouse Pulmonary Adenoma Susceptibility 1 Locus Is an Expression QTL Modulating Kras-4A
Pulmonary adenoma susceptibility 1 (Pas1) is the major locus responsible for lung tumor susceptibility in mice; among the six genes mapping in this locus, Kras is considered the best candidate for Pas1 function although how it determines tumor susceptibility remains unknown. In an (A/J × C57BL/6)F4 intercross population treated with urethane to induce lung tumors, Pas1 not only modulated tumor ...
متن کاملCis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.
Immunoglobulin variable region exons are assembled from discontinuous variable (V), diversity (D), and joining (J) segments by the process of V(D)J recombination. V(D)J rearrangements of the immunoglobulin heavy chain (IgH) locus are tightly controlled in a tissue-specific, ordered and allele-specific manner by regulating accessibility of V, D, and J segments to the recombination activating gen...
متن کاملCis-acting elements in its 3′ UTR mediate post-transcriptional regulation of KRAS
Multiple RNA-binding proteins and non-coding RNAs, such as microRNAs (miRNAs), are involved in post-transcriptional gene regulation through recognition motifs in the 3' untranslated region (UTR) of their target genes. The KRAS gene encodes a key signaling protein, and its messenger RNA (mRNA) contains an exceptionally long 3' UTR; this suggests that it may be subject to a highly complex set of ...
متن کاملCharacterization of cis- and trans-acting elements in the imprinted human SNURF-SNRPN locus
The imprinted SNRPN locus is a complex transcriptional unit that encodes the SNURF and SmN polypeptides as well as multiple non-coding RNAs. SNRPN is located within the Prader-Willi and Angelman syndrome (PWS/AS) region that contains multiple imprinted genes, which are coordinately regulated by a bipartite imprinting center (IC). The SNRPN 5' region co-localizes with the PWS-IC and contains two...
متن کاملcis-ACTING SEQUENCE ELEMENTS IN ALPHAVIRUS RNAS
INTRODUCTION................................................... 492 The Cast of Characters ................................................... 492 Dispersal of Alphaviruses................................................... 494 Full-Length Clones of Alphaviruses ................................................... 494 STRUCTURE OF ALPHAVIRUSES ................................................... ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncogene
سال: 2008
ISSN: 0950-9232,1476-5594
DOI: 10.1038/onc.2008.194